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Best Western Travel Programs

Missouri

Ride Route 66

Explore the history, adventure and kitsch of America's famous 'Mother Road', Best Western-style. Journey along the 2,400-mile Route 66 and take part in the monthly Scavenger Hunt to win great prizes!

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Make reservations at Best Western branded hotels, travel itineraries with TripIt^®, save favorite locations, share with friends & much more with the Best Western to Go! mobile app.

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Hotels in Sikeston, MO

A fine and pleasant city, Sikeston is set just north of the Missouri Bootheel in eastern Missouri. Enjoy the scenic drive to Festus, or zip along I-57 east just a few miles and explore the mighty Mississippi River. Guests of the Best Western hotel in Sikeston enjoy watching the raw grit of the races at SEMO Motor Speedway, just 20 minutes north and right off I-55. Sports fans are only a couple hours away from St. Louis. With an array of local sports local sports, don't miss Busch Stadium, home to the World Series Champion St. Louis Cardinals, or visit the Edward Jones Dome and watch the Rams fight for shot at the Lombardi Trophy. Whatever the season, and whatever the reason, make a trip into southeastern Missouri today and stay in Sikeston.